HeathcareFirst HIV drug developed in China is clinically safe

First HIV drug developed in China is clinically safe

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The first medicine developed in China for the treatment of HIV proved to be safe and effective in the results of clinical trials, the Xinhua news agency reported today.

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Albuvirtide (ABT), the generic name it has received, belongs to the group of drugs against HIV called fusion inhibitors, which block the virus from entering certain cells of the immune system.

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The results of the phase III clinical trial, which has lasted for 48 weeks, were published in the “Journal of Infection” and showed that the combination of ABT with the antiretroviral Kaletra revealed a good safety profile.

For the trials, pharmaceutical company Frontier Biotech, developer of ABT, recruited 418 HIV patients in China who had previously failed to suppress the virus with oral antiviral drugs.

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After taking ABT and Kaletra for four weeks, 41% of the participants saw their plasma viral load fall below 50 copies/mL, meaning HIV viruses were “undetected”, while 83% % had been effectively treated as about 99% of the HIV viruses in their bodies were inhibited, according to the study.

The clinical trial, which began in 2013 is the first of its kind in the world to use a two-drug regimen and the first carried out among an all-Asian sample.

In May 2018, ABT received the new drug certificate from the State Administration of Medicines in China, and in October of the same year it was included as one of the main antiretroviral drugs available in the Chinese guidelines for HIV diagnosis and treatment. .

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According to the National Health Commission, in 2020 about 1.25 million patients were living with HIV in China, a country where about 80,000 people contract the virus each year.

Source: Elcomercio

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