COVID-19 | How effective is the third dose of Pfizer against the Delta variant?

A study published in The Lancet magazine indicates that a third dose of the Pfizer / BioNTech vaccine is effective in reducing severe outcomes related to the COVID-19, in comparison with those individuals who have received two doses of the preparation at least five months before.

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Responsible for this work is the Israeli Clalit Research Institute, in collaboration with researchers from Harvard University (United States), who have examined the

The study was carried out between July 30 and September 23, 2021, coinciding with the fourth wave of coronavirus infections and diseases in Israel, during which the Delta variant (B.1.617.2) (with very few exceptions), informs the Clalit in a note.

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The researchers reviewed data from 728,321 individuals 12 years of age and older who had received the third dose of the BNT162b2 vaccine (Pfizer). These were matched with 728,321 other individuals who had received only two injections of the preparation at least five months earlier.

For the comparison, a broad set of demographic, geographic and health characteristics associated with the risk of infection was taken into account, as

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The results show that, compared to individuals who received only two doses five months earlier, those who received three doses of the vaccine (7 days or more after the third dose) had

92% lower risk of serious illness and 81% lower risk of death.

It was found that the effectiveness of the vaccine was similar for the different sexes, age groups (40-69 years and more than 70) and number of comorbidities.

The study also included a population-level analysis that found that for each age group between 7 and 10 days after that age group was eligible for the third dose.

“The results convincingly show that the third dose is highly effective against severe COVID-19-related outcomes in different age groups and population subgroups, one week after the third dose,” says Ran Balicer, lead author of the study.

According to the researcher, “These data should informed policies ”.

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